Key result
IGFBP-1 levels were inversely associated with maximal carotid intima-media thickness (r = -0.42, P<0.001) in patients with type 2 diabetes.
Why the study?
Is the insulin-like growth factor (IGF) system associated with carotid intima-media thickness in patients with type 2 diabetes?
Population
239 type 2 diabetic participants in the Fenofibrate Intervention and Event Lowering in Diabetes Study aged…
Design
Cross-sectional
Authors
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Lower IGFBP-1 marks carotid IMT thickening in T2D; leaves open its value as an atherosclerosis biomarker.
Cross-Sectional (n=239)
Is the insulin-like growth factor (IGF) system associated with carotid intima-media thickness in patients with type 2 diabetes?
Effect estimate: r = -0.42
p-value: p=<0.001
Reduced IGFBP-1 is independently associated with increased carotid intima-media thickness in patients with type 2 diabetes, suggesting it may serve as a marker for atherosclerosis.
Leinonen et al. (2002) conducted a cross-sectional in Type 2 diabetes (n=239). IGFBP-1 levels was evaluated on carotid intima-media thickness (IMT) (r = -0.42, p=<0.001). IGFBP-1 levels were inversely associated with maximal carotid intima-media thickness (r = -0.42, P<0.001) in patients with type 2 diabetes.
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