Key result
Among acute myocardial infarction survivors, female sex was associated with a higher risk of 6-month heart failure hospitalisation compared to males (6.4% vs 5.8%; HR 1.13; 95% CI 1.05-1.21; P<0.001).
Why the study?
The study was conducted to evaluate sex differences in 6-month heart failure hospitalisation risk among acute myocardial infarction survivors.
Does female sex increase the risk of heart failure hospitalization in acute myocardial infarction survivors?
Population
237 549 adult AMI survivors from the US Nationwide Readmissions Database
Comparison
Females vs males
Design
Retrospective cohort analysis
Follow-up
6 months
Authors
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May warrant closer post-MI HF monitoring in women; hypothesis-generating for sex-specific prevention trials.
Cohort (n=237,549)
Yes
Does female sex increase the risk of heart failure hospitalization in acute myocardial infarction survivors?
Hazard Ratio: 1.13 (95% CI 1.05–1.21)
Absolute Event Rate: 6.4% vs 5.8%
p-value: p=<0.001
Female survivors of acute myocardial infarction have a significantly higher risk of heart failure hospitalization within 6 months compared to males, even after adjusting for baseline differences.
Yandrapalli et al. (2021) conducted a cohort in acute myocardial infarction (n=237,549). Female sex vs. Male sex was evaluated on Heart failure hospitalisation within 6 months (HR 1.13, 95% CI 1.05 to 1.21, p=<0.001). Among acute myocardial infarction survivors, female sex was associated with a higher risk of 6-month heart failure hospitalisation compared to males (6.4% vs 5.8%; HR 1.13; 95% CI 1.05-1.21; P<0.001).
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