Key result
In patients with advanced heart failure, Sirt1 expression in cardiomyocytes was down-regulated to 54.92% of healthy control levels, which was associated with decreased antioxidants and increased proapoptotic molecules.
Authors
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May support Sirt1 as a future therapeutic target in advanced HF; leaves open whether modulation improves outcomes in prospective trials.
Cross-Sectional (n=20)
No
Absolute Event Rate: 54.92% vs 100%
Lu et al. (2014) conducted a cross-sectional in Advanced heart failure (dilated cardiomyopathy) (n=20). Advanced heart failure vs. Healthy donor hearts was evaluated on Sirt1 expression in cardiomyocytes. In patients with advanced heart failure, Sirt1 expression in cardiomyocytes was down-regulated to 54.92% of healthy control levels, which was associated with decreased antioxidants and increased proapoptotic molecules.
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