What question did this study set out to answer?

To evaluate whether omitting axillary clearance improves quality of life without compromising disease-free or overall survival in older women with clinically node-negative operable breast cancer.

December 13, 2005Journal of Clinical Oncology

Randomized Trial Comparing Axillary Clearance Versus No Axillary Clearance in Older Patients With Breast Cancer: First Results of International Breast Cancer Study Group Trial 10-93

View Full Paper

Ask AI

Bookmark

To evaluate whether omitting axillary clearance improves quality of life without compromising disease-free or overall survival in older women with clinically node-negative operable breast cancer.
Randomized trial (IBCSG Trial 10-93) conducted between 1993 and 2002 enrolling 473 women aged ≥ 60 years with clinically node-negative operable breast cancer.
Participants were randomly assigned to primary surgery with axillary clearance (n = 234) or primary surgery without axillary clearance (n = 239), followed by 5 years of adjuvant tamoxifen.
Adverse effects on patient- and physician-assessed quality of life were highest immediately postoperatively in the axillary clearance arm, with differences diminishing within 6 to 12 months.
At a median follow-up of 6.6 years, 6-year disease-free survival was 67% with axillary clearance versus 66% without clearance (HR 1.06; 95% CI, 0.79 to 1.42; P = .69).
Six-year overall survival was 75% with axillary clearance versus 73% without clearance (HR 1.05; 95% CI, 0.76 to 1.46; P = .77).

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Randomized trial demonstrates omitting axillary clearance preserves survival and improves early quality of life in older breast cancer patients, suggesting routine axillary surgery can be avoided.

Cite This Study

Cm et al. (2005) studied this question.

synapsesocial.com/papers/6a7737c4df493903fd1ec0e3 https://doi.org/10.1200/jco.2005.01.5784

View Full Paper

Ask AI

Bookmark

Implication

Randomized trial demonstrates omitting axillary clearance preserves survival and improves early quality of life in older breast cancer patients, suggesting routine axillary surgery can be avoided.

Randomized Trial Comparing Axillary Clearance Versus No Axillary Clearance in Older Patients With Breast Cancer: First Results of International Breast Cancer Study Group Trial 10-93

Key Points

Discussion

Implication

Cite This Study

Randomized Trial Comparing Axillary Clearance Versus No Axillary Clearance in Older Patients With Breast Cancer: First Results of International Breast Cancer Study Group Trial 10-93

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider