Key result
None of 27 modifiable risk factors were significantly associated with heart failure after Bonferroni correction, though educational attainment showed a suggestive association (OR 0.57, 95% CI 0.33-0.99).
Why the study?
Observational studies have linked lifestyle, dietary, adiposity, biochemical, and clinical measures with heart failure, but whether these associations are causal remains unclear.
Do genetically predicted modifiable risk factors causally affect the incidence or mortality of heart failure?
Observational (n=23,754)
Do genetically predicted modifiable risk factors causally affect the incidence or mortality of heart failure?
Odds Ratio: 0.57 (95% CI 0.33–0.99)
p-value: p=0.049
Mendelian randomization analysis found no significant causal associations between 27 modifiable risk factors and heart failure after multiple testing correction, though suggestive links exist for education, lipids, and blood pressure.
Does not support targeting 27 factors for HF prevention; leaves open education's suggestive role for larger validation studies.
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Wang et al. (2021) conducted an observational in Heart failure (n=23,754). 27 modifiable risk factors was evaluated on incident heart failure (educational attainment) (OR 0.57, 95% CI 0.33-0.99, p=0.049). None of 27 modifiable risk factors were significantly associated with heart failure after Bonferroni correction, though educational attainment showed a suggestive association (OR 0.57, 95% CI 0.33-0.99).
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