Key Points
- To establish reference intervals for platelet count and mean platelet volume and assess their variation across diverse clinical conditions.
- Analyzed 5,000 unselected clinical blood specimens using a Coulter Model S-Plus Counter.
- Measured circulating platelet counts and mean platelet volume (MPV) in healthy adults and compared them across pregnancy and various pathological states.
- Circulating platelet counts and MPV demonstrated an inverse relationship, with normal adult reference ranges covering 150 to 450 × 10^9/l for count and 7.0 to 10.5 fl for MPV in nearly 95% of individuals.
- Thrombocytosis occurred in iron deficiency anaemia, rheumatoid arthritis, trauma, and acute blood loss.
- Patients with pre-eclampsia and late-pregnancy uncomplicated hypertension exhibited lower platelet counts and higher MPV than normal controls.
Structured PICO
PPopulation5000 unselected blood specimens
OOutcomeRelationship between platelet count and mean platelet volume (MPV)surrogate
Demonstrates an inverse relationship between platelet count and mean platelet volume, establishing normal ranges and identifying variations in specific clinical conditions.