Population
Heterologously expressed pacemaker (HCN1 and HCN2) channels
Comparison
External permeant and non-permeant ions, and… vs Standard external K+ concentration / wild-type…
Design
Preclinical
Authors
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Extends HCN channel biophysics in animal models; leaves open translation to human cardiac pacemaking.
Demonstrates that gating and permeation of HCN channels are coupled, and that modulation of this coupling by external potassium is isoform-specific.
Azene et al. (2003) studied this question.
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