What question did this study set out to answer?

To evaluate the safety, tolerance, and therapeutic efficacy of combining peritonectomy procedures with intraperitoneal chemohyperthermia in patients presenting with peritoneal carcinomatosis.

February 27, 2003Journal of Clinical Oncology

Surgery Combined With Peritonectomy Procedures and Intraperitoneal Chemohyperthermia in Abdominal Cancers With Peritoneal Carcinomatosis: A Phase II Study

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Authors

OGOlivier GléhenHospices Civils de Lyon FMFrançois MithieuxHôpital Privé Jean Mermo DOD. OsinskyKyiv City Clinical Oncology Center

Discussion

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Implication

Phase II trial demonstrates improved two-year survival following complete resection with chemohyperthermia in peritoneal carcinomatosis, highlighting the value of careful patient selection.

Key Points

To evaluate the safety, tolerance, and therapeutic efficacy of combining peritonectomy procedures with intraperitoneal chemohyperthermia in patients presenting with peritoneal carcinomatosis.
Conducted a prospective phase II study enrolling 56 patients (35 females, mean age 49.3 years) with peritoneal carcinomatosis from colorectal, ovarian, gastric, pseudomyxoma peritonei, mesothelioma, and other origins.
Performed primary tumor resection alongside peritonectomy procedures and closed-circuit intraperitoneal chemohyperthermia with mitomycin C, cisplatin, or both at inflow temperatures between 46°C and 48°C.
Macroscopic complete resection was achieved in 27 of 56 cases, with an overall treatment mortality rate of 1 of 56 and a morbidity rate of 16 of 56.
The 2-year survival rate was significantly higher for patients receiving macroscopic complete resection at 79.0% compared to 44.7% for patients without complete resection (P = 0.001).

Cite This Study

Gléhen et al. (2003) studied this question.

synapsesocial.com/papers/6a77516ea7498e5110ae79d3 https://doi.org/10.1200/jco.2003.06.139

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Implication

Phase II trial demonstrates improved two-year survival following complete resection with chemohyperthermia in peritoneal carcinomatosis, highlighting the value of careful patient selection.

Surgery Combined With Peritonectomy Procedures and Intraperitoneal Chemohyperthermia in Abdominal Cancers With Peritoneal Carcinomatosis: A Phase II Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Surgery Combined With Peritonectomy Procedures and Intraperitoneal Chemohyperthermia in Abdominal Cancers With Peritoneal Carcinomatosis: A Phase II Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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