Key result
Cerebral atrophy index is linked to ~50% higher odds of prestroke cognitive impairment in SVD.
Observational (n=78)
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Understanding the determinants of prestroke cognitive impairment (PCI) in stroke associated with small vessel disease (SVD) may shed light on how to prevent further cognitive deterioration after stroke. We administered the Informant Questionnaire on Cognitive Decline (IQCODE) to close informants of 78 consecutive stroke patients who had SVD. PCI, as defined by an average score of IQCODE > or =3.4 was found in 19 (24%) patients. Regression analyses were performed on the following risk factors for PCI: age, years of education, gender, previous stroke, volume of white matter changes, measures of silent lacunes, cerebral atrophy index, medial temporal lobe atrophy and frontal lobe atrophy. Multivariate regression analyses revealed that only cerebral atrophy index (OR 1.5, CI 1.2-1.9, p < 0.001) predicted PCI among patients with SVD.
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Mok et al. (2005) conducted an observational in Stroke associated with small vessel disease (SVD) (n=78). Cerebral atrophy index was evaluated on Prestroke cognitive impairment (defined as an average IQCODE score ≥3.4) (OR 1.5, 95% CI 1.2-1.9, p=<0.001). Cerebral atrophy index independently predicted prestroke cognitive impairment in patients with stroke associated with small vessel disease (OR 1.5; 95% CI 1.2-1.9; p < 0.001).
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