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October 1, 1972Journal of VirologyOpen Access

Inhibition of Cleavage of Large Poliovirus-Specific Precursor Proteins in Infected HeLa Cells by Inhibitors of Proteolytic Enzymes

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Population

Poliovirus-infected HeLa cells

Design

Preclinical

Authors

DSDonald F. SummersUniversity of OtagoESElliott ShawTulane UniversityMSMargaret L. StewartUniversity of East Anglia

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Implication

Inhibitors of chymotrypsin interfere with the cleavage of large poliovirus-specific precursor proteins in infected HeLa cells.

Structured PICO

P
Population
Poliovirus-infected HeLa cells
I
Intervention
Inhibitors of chymotrypsin
O
Outcome
Post-translational cleavage of large poliovirus-specific polypeptides (molecular weight 100,000 to 250,000)surrogate

Inhibitors of chymotrypsin interfere with the cleavage of large poliovirus-specific precursor proteins in infected HeLa cells.

Cite This Study

Summers et al. (1972) studied this question.

synapsesocial.com/papers/6a77583ef6b553d308ae6ef7https://doi.org/10.1128/jvi.10.4.880-884.1972
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Pactamycin on Synthesis of Poliovirus Proteins: a Method for Genetic Mapping1971 · 128 citations
  2. 2Determination of the Gene Sequence of Poliovirus with Pactamycin1971 · 66 citations
  3. 3Polypeptide cleavages in the formation of poliovirus proteins.1968 · 351 citations
  4. 4Molecular Weight of Poliovirus Ribonucleic Acid1969 · 108 citations
  5. 5POLYRIBOSOMES IN NORMAL AND POLIOVIRUS-INFECTED HELA CELLS AND THEIR RELATIONSHIP TO MESSENGER-RNA1963 · 469 citations