Key result
Obese patients with type 2 diabetes had significantly reduced insulin-stimulated blood flow compared to lean subjects (+20.8% vs +50.7% from baseline, P<0.05).
Why the study?
Does obesity and type 2 diabetes alter skeletal muscle NO synthase and endothelin-1 expression and impair insulin-stimulated blood flow compared to lean insulin-sensitive individuals?
Population
32 subjects: 10 obese with type 2 diabetes, 11 lean insulin-sensitive subjects, and 11 medication-naïve…
Comparison
Hyperinsulinemic-euglycemic clamp with vastus… vs Lean insulin-sensitive subjects and obese…
Design
Cross-sectional
Authors
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Reduced insulin-stimulated blood flow may reflect vascular insulin resistance in obese T2D; hypothesis-generating and requires validation in larger studies.
Observational (n=32)
Does obesity and type 2 diabetes alter skeletal muscle NO synthase and endothelin-1 expression and impair insulin-stimulated blood flow compared to lean insulin-sensitive individuals?
Absolute Event Rate: 20.8% vs 50.7%
p-value: p=<0.05
Higher basal skeletal muscle expression of ET-1 and reduced peNOS/eNOS may contribute to reduced insulin-stimulated blood flow in obese T2D patients.
Reynolds et al. (2016) conducted an observational in Type 2 diabetes and obesity (n=32). Obesity and Type 2 Diabetes vs. Lean insulin-sensitive subjects was evaluated on Insulin-stimulated blood flow (% increase from baseline) (p=<0.05). Obese patients with type 2 diabetes had significantly reduced insulin-stimulated blood flow compared to lean subjects (+20.8% vs +50.7% from baseline, P<0.05).
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