Why the study?
Is there an association between ACE gene polymorphism and insulin resistance in never-treated hypertensive patients?
Population
296 subjects, comprising 200 never-treated hypertensive patients and 96 normotensive controls.
Comparison
ACE gene polymorphism (DD, ID, II genotypes) vs Normotensive controls and comparison across…
Design
Case-control
Authors
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ACE DD genotype was associated with higher insulin resistance in never-treated hypertension; hypothesis-generating, requires prospective confirmation before clinical relevance.
Is there an association between ACE gene polymorphism and insulin resistance in never-treated hypertensive patients?
The ACE DD genotype is associated with significantly higher insulin resistance in never-treated hypertensive patients compared to other genotypes.
Perticone et al. (2001) studied this question.
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