Key result
In a rat model of myocardial infarction, sodium hydrosulfide reduced mortality to 27.5% compared with 35% in vehicle-treated animals (P < 0.05).
Why the study?
Does sodium hydrosulfide reduce mortality and infarct size in a rat model of myocardial infarction?
Population
Rat model of myocardial infarction in vivo (n=80)
Comparison
Sodium hydrosulfide 14 micromol/kg or… vs Vehicle
Design
Preclinical, Animals were randomly divided into three groups
Follow-up
2 days after MI
Authors
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May support H2S cardioprotection in experimental MI; leaves open translation to human therapy.
RCT (n=80)
randomly divided
Does sodium hydrosulfide reduce mortality and infarct size in a rat model of myocardial infarction?
Absolute Event Rate: 27.5% vs 35%
p-value: p=< 0.05
Endogenous and exogenous hydrogen sulfide demonstrates cardioprotective effects by reducing mortality and infarct size in a rat model of myocardial infarction.
Zhu et al. (2006) conducted an RCT in Myocardial infarction (n=80). Sodium hydrosulfide (NaHS) vs. Vehicle was evaluated on Mortality (p=< 0.05). In a rat model of myocardial infarction, sodium hydrosulfide reduced mortality to 27.5% compared with 35% in vehicle-treated animals (P < 0.05).
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