Stool DNA Testing and Colon Cancer Prevention: Another Step Forward

Editorials7 October 2008Stool DNA Testing and Colon Cancer Prevention: Another Step ForwardDaniel C. Chung, MDDaniel C. Chung, MDFrom Massachusetts General Hospital, Boston, MA 02114.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-7-200810070-00013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Despite the recognition that colon cancer is largely preventable, it remains the second leading cause of cancer-related deaths in the United States. Historically, screening approaches have sought to detect established cancer, but the identification of precancerous adenomatous polyps is clearly the preferable goal. Not all adenomas progress to cancer, but those that are larger than 1 cm or contain villous histology or high-grade dysplasia are most likely to do so. The current multisociety guidelines now emphasize detection of precancerous polyps as the most effective strategy to prevent deaths from colon cancer, and structural examinations, such as colonoscopy, are recommended for ...References1. Levin B, Lieberman DA, McFarland B, Andrews KS, Brooks D, Bond J; et al.. American Cancer Society Colorectal Cancer Advisory Group. Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. Gastroenterology. 2008;134:1570-95. [PMID: 18384785] CrossrefMedlineGoogle Scholar2. Lieberman DA, Weiss DG; Veterans Affairs Cooperative Study Group 380. One-time screening for colorectal cancer with combined fecal occult-blood testing and examination of the distal colon. N Engl J Med. 2001;345:555-60. [PMID: 11529208] CrossrefMedlineGoogle Scholar3. Fearon ER, Vogelstein B. 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[PMID: 17310048] LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Massachusetts General Hospital, Boston, MA 02114.Disclosures:Grants received: D.C. Chung (EXACT Sciences, 2001–2003).Corresponding Author: Daniel C. Chung, MD, Gastrointestinal Unit and Cancer Center, GRJ 825, Massachusetts General Hospital, 50 Blossom Street, Boston, MA 02114; e-mail, [email protected]org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoStool DNA and Occult Blood Testing for Screen Detection of Colorectal Neoplasia David A. Ahlquist , Daniel J. Sargent , Charles L. Loprinzi , Theodore R. Levin , Douglas K. Rex , Dennis J. Ahnen , Kandice Knigge , M. Peter Lance , Lawrence J. Burgart , Stanley R. Hamilton , James E. Allison , Michael J. Lawson , Mary E. Devens , Jonathan J. Harrington , and Shauna L. Hillman Metrics Cited by1 H NMR Spectroscopy of Fecal Extracts Enables Detection of Advanced Colorectal NeoplasiaValidation of methylation-sensitive high-resolution melting (MS-HRM) for the detection of stool DNA methylation in colorectal neoplasmsLowly Expressed Ribosomal Protein S19 in the Feces of Patients with Colorectal CancerFecal Molecular Markers for Colorectal Cancer ScreeningCost-effectiveness of Colorectal Cancer ScreeningRapid detection of low-abundance K-ras mutation in stools of colorectal cancer patients using chip-based temperature gradient capillary electrophoresisFem1b antigen in the stool of ApcMin mice as a biomarker of early Wnt signaling activation in intestinal neoplasiaStool DNA Testing to Screen for Colorectal Cancer in the Medicare Population A Cost-Effectiveness AnalysisIris Lansdorp-Vogelaar, PhD, Karen M. Kuntz, ScD, Amy B. Knudsen, PhD, Janneke A. Wilschut, MS, Ann G. Zauber, PhD, and Marjolein van Ballegooijen, MD, PhDCost-effectiveness of colorectal cancer screening – An overviewComprehensive Outpatient Health Assessment 7 October 2008Volume 149, Issue 7Page: 509-510KeywordsAdenomasCancer screeningColonoscopyColorectal cancerDNAGenetic testingHematologic testsMethylationMutationSpecificity ePublished: 7 October 2008 Issue Published: 7 October 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...