Key result
Mitral valve prolapse was not associated with changes in aortic elastic properties, with no significant differences in aortic strain (p=0.359), stiffness index (p=0.388), or distensibility (p=0.346) compared to healthy controls.
Why the study?
Connective tissue alteration in MVP leads to increased leaflet elasticity, and aortic elasticity may also differ in these patients.
Do aortic elastic properties differ in patients with mitral valve prolapse compared to healthy controls?
Case-Control (n=75)
No
Do aortic elastic properties differ in patients with mitral valve prolapse compared to healthy controls?
Aortic elastic properties do not differ between patients with mitral valve prolapse and healthy individuals, suggesting these parameters are not altered by the connective tissue deterioration seen in MVP.
Objective: Mitral valve prolapse (MVP) is one of the most frequently seen cardiac disorders. The basic pathophysiologic mechanism is deterioration in the connective tissue leading to increased elasticity of mitral leaflets. Elasticity of the aorta which is a well established predictor of adverse cardiovascular outcomes may also differ in these patients when alteration in the connective tissue is taken into account. The aim of this study is to investigate the elastic properties of the aorta in patients with MVP. Method: Thirty seven patients with MVP and 38 healthy controls were evaluated in terms of aortic elastic properties using aortic strain, aortic stiffness index and aortic distensibility. Results: Median value for aortic strain was 0.07 (0.0338-0.231) in MVP group and 0.079 (0.0345-0.28) in the control group (p=0.359). Aortic stiffness was calculated on the basis of aortic strain. The mean value for stiffness index was 6.87 ± 3.59 and 6.21 ± 2.83 in the MVP and control groups respectively (p=0.388). Distensibility of the aorta was quantified with a median value of 3286 (1229-12700) in patients with MVP and 3400 (1087-13790) in healthy subjects (p=0.346). Eventually, when the aortic elastic parameters were compared (aortic strain, stiffness index and distensibility), no difference was found between MVP and control groups. Conclusions: The elastic properties of the aorta do not differ in patients with MVP when compared to healthy individuals. It will not be accurate to predict long term cardiovascular outcomes based on elastic properties of the aorta in patients with MVP.
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Karagöz et al. (2019) conducted a case-control in Mitral valve prolapse (n=75). Mitral valve prolapse vs. Healthy controls was evaluated on Aortic strain (p=0.359). Mitral valve prolapse was not associated with changes in aortic elastic properties, with no significant differences in aortic strain (p=0.359), stiffness index (p=0.388), or distensibility (p=0.346) compared to healthy controls.
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