Key result
Primary mitral valve prolapse is linked to impaired aortic elastic properties and increased arterial stiffness.
Why the study?
Primary mitral valve prolapse (MVP) represents a generalized connective tissue disease in which aortic elastic properties may be expected to be increased, prompting this study to determine aortic elasticity in primary MVP.
Case-Control (n=40)
Altered aortic elasticity in primary mitral valve prolapse warrants confirmation; supports generalized connective tissue involvement but leaves clinical implications open.
BACKGROUND: Mitral valve prolapse (MVP) is the most common valvular heart disease representing a generalized disease of connective tissue in the primary form. Elastic properties of the aorta with primary MVP may be expected to be increased. We aimed to determine the aortic elasticity in the primary form of MVP. METHODS AND RESULTS: Twenty male patients with a primary form of MVP not having any sign of Marfan syndrome and joint hyperlaxity syndrome and twenty healthy individuals were included in the study. Aortic strain, aortic distensibility index and aortic stiffness index were calculated by using aortic diameters obtained by echocardiography and blood pressures measured by sphygmomanometer. When comparing the MVP group and the control group it was found that the aortic stiffness index was increased (P < 0.05) whereas the aortic distensibility and strain index were decreased (P < 0.05) in the MVP group. There was no significant difference between the characteristics of the groups (P > 0.05). CONCLUSION: We concluded that the elastic properties of the aorta were decreased in the primary form of MVP, unexpectedly.Therefore, results of decreased aortic elasticity should also be followed up in patients with MVP.
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Kardeşoğlu et al. (2007) conducted a case-control in Primary mitral valve prolapse (MVP) (n=40). Primary mitral valve prolapse vs. Healthy individuals without mitral valve prolapse was evaluated on Aortic elastic properties (aortic stiffness index, aortic distensibility index, and aortic strain) (p=<0.05). Primary mitral valve prolapse was associated with a significantly increased aortic stiffness index and decreased aortic distensibility and strain indices compared with healthy controls (P < 0.05).
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