Key result
Spontaneous venous thrombosis was associated with impaired aortic elastic properties, including a significantly increased aortic stiffness index (6.5 vs 6.0; P=0.03) compared to healthy controls.
Why the study?
Do patients with spontaneous venous thromboembolism have impaired aortic elastic properties compared to healthy subjects?
Case-Control (n=61)
Do patients with spontaneous venous thromboembolism have impaired aortic elastic properties compared to healthy subjects?
Patients with spontaneous venous thromboembolism exhibit impaired aortic elastic properties, suggesting a potential link between endothelial dysfunction and VT pathogenesis.
No immediate change to venous thrombosis care; leaves open shared endothelial pathways requiring prospective confirmation.
OBJECTIVES: The relationship between venous thrombosis (VT) and atherosclerosis is controversial in recent studies. Aortic elastic properties have a predictive value in detecting early stages of atherosclerosis. The aim of this study is to evaluate the relationship between aortic elastic properties and VT. METHODS: Elastic properties of aorta in patients with spontaneous VT, without history of known cardiovascular disease and cardiovascular risk factors (n: 31), and in healthy subjects without cardiovascular risk factors (n: 30) were compared. Elastic properties of the aorta were assessed with transthoracic echocardiography. RESULTS: A significant increase in aortic stiffness index (6.5 ± 1.0 versus 6 ± 0.7, P = 0.03) and a significant decrease in aortic strain and aortic distensibility were found in patients with VT compared with healthy subjects (8.4 ± 7 versus 13 ± 8, P = 0.01, 4.9 ± 4.8 versus 6.5 ± 4.4, P = 0.03, respectively). CONCLUSIONS: Elastic properties of aorta in patients with spontaneous VT were impaired. These results may support the role of endothelial dysfunction in the pathogenesis of VT.
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Duran et al. (2010) conducted a case-control in Venous thromboembolism (n=61). Spontaneous venous thrombosis vs. Healthy subjects without cardiovascular risk factors was evaluated on Aortic stiffness index (p=0.03). Spontaneous venous thrombosis was associated with impaired aortic elastic properties, including a significantly increased aortic stiffness index (6.5 vs 6.0; P=0.03) compared to healthy controls.
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