Key result
Transcatheter aortic valve implantation significantly improved aortic stiffness, aortic strain, aortic distensibility, and left ventricular mass index at 6 months (all p<0.001).
Why the study?
Aortic stiffness predicts cardiovascular mortality and morbidity and contributes to symptom burden and clinical outcomes in aortic stenosis, but the effect of TAVI on echocardiographic aortic elasticity parameters in severe aortic stenosis with preserved ejection fraction needed evaluation.
Does transcatheter aortic valve implantation (TAVI) improve aortic elasticity parameters in patients with severe aortic stenosis and preserved ejection fraction?
Cohort (n=55)
Does transcatheter aortic valve implantation (TAVI) improve aortic elasticity parameters in patients with severe aortic stenosis and preserved ejection fraction?
p-value: p=<0.001
TAVI improves aortic elastic properties and left ventricular mass index in patients with severe aortic stenosis and preserved ejection fraction.
TAVI was associated with improved aortic elasticity at 6 months in severe AS; leaves open prognostic value and need for controlled trials.
INTRODUCTION: Aortic stiffness is an important risk factor that reflects the mechanical tension and elasticity of the aorta and predicts cardiovascular mortality and morbidity. However, it has been found that aortic stiffness contributes to both symptom burden and clinical outcomes in patients with aortic stenosis (AS). In our study, we aimed to evaluate the effect of transcatheter aortic valve implantation (TAVI) on aortic elasticity parameters by echocardiography in patients with severe aortic stenosis, especially with preserved ejection fraction. METHODS: A total of 55 consecutive patients with symptomatic severe AS who underwent TAVI were included in the study. Demographic data, echocardiographic and aortic elasticity measurements of all patients were measured before and 6 months after the procedure. To evaluate the elastic properties of the aorta, aortic strain, distensibility and stiffness index were calculated. RESULTS: Left ventricular mass index (LVMI) (p <0.001) and aortic stiffness (p <0.001) were decreased, while aortic strain (p <0.001) and aortic distensibility (p <0.001) were found to be increased in the measurements performed at 6 months after TAVI. In the regression analysis, age and LVMI were found to be independent predictors for predicting improvement in aortic stiffness, on the other hand, LVMI also independently predicted the increase in aortic distensibility. CONCLUSION: Improvement in aortic elastic properties and left ventricular functions were found in patients who underwent TAVI. Age and LVMI were observed to predict the improvement in stiffness and distensibility of the aorta in patients undergoing TAVI, especially in AS patients with preserved ejection fraction.
No takes yet. Share an insight, caveat, or question.
Bayramoğlu et al. (2022) conducted a cohort in Severe aortic stenosis with preserved ejection fraction (n=55). Transcatheter aortic valve implantation (TAVI) vs. Baseline (pre-procedure) was evaluated on Aortic elasticity parameters (aortic strain, distensibility, stiffness index) and left ventricular mass index (LVMI) (p=<0.001). Transcatheter aortic valve implantation significantly improved aortic stiffness, aortic strain, aortic distensibility, and left ventricular mass index at 6 months (all p<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: