Key result
Treatment of symptomatic severe aortic stenosis by SAVR, but not TAVI, was associated with a significant increase in aortic pulse wave velocity from 6.38 to 11.01 m/s (p=0.001) at 6 months.
Why the study?
Does TAVI compared to SAVR prevent increases in aortic stiffness in patients with high-risk symptomatic severe aortic stenosis?
Cohort (n=72)
Single-blind
Yes
Does TAVI compared to SAVR prevent increases in aortic stiffness in patients with high-risk symptomatic severe aortic stenosis?
Absolute Event Rate: 11.01% vs 10.23%
SAVR, but not TAVI, is associated with an increase in aortic stiffness at 6 months in patients with severe aortic stenosis.
SAVR-linked aortic stiffness rise should not yet alter valve selection; leaves open whether TAVI better preserves compliance in severe AS.
BACKGROUND: Aortic stiffness is increasingly used as an independent predictor of adverse cardiovascular outcomes. We sought to compare the impact of transcatheter aortic valve implantation (TAVI) and surgical aortic valve replacement (SAVR) upon aortic vascular function using cardiovascular magnetic resonance (CMR) measurements of aortic distensibility and pulse wave velocity (PWV). METHODS AND RESULTS: A 1.5 T CMR scan was performed pre-operatively and at 6 m post-intervention in 72 patients (32 TAVI, 40 SAVR; age 76 ± 8 years) with high-risk symptomatic severe aortic stenosis. Distensibility of the ascending and descending thoracic aorta and aortic pulse wave velocity were determined at both time points. TAVI and SAVR patients were comparable for gender, blood pressure and left ventricular ejection fraction. The TAVI group were older (81 ± 6.3 vs. 72.8 ± 7.0 years, p < 0.05) with a higher EuroSCORE II (5.7 ± 5.6 vs. 1.5 ± 1.0 %, p < 0.05). At 6 m, SAVR was associated with a significant decrease in distensibility of the ascending aorta (1.95 ± 1.15 vs. 1.57 ± 0.68 × 10(-3)mmHg(-1), p = 0.044) and of the descending thoracic aorta (3.05 ± 1.12 vs. 2.66 ± 1.00 × 10(-3)mmHg(-1), p = 0.018), with a significant increase in PWV (6.38 ± 4.47 vs. 11.01 ± 5.75 ms(-1), p = 0.001). Following TAVI, there was no change in distensibility of the ascending aorta (1.96 ± 1.51 vs. 1.72 ± 0.78 × 10(-3)mmHg(-1), p = 0.380), descending thoracic aorta (2.69 ± 1.79 vs. 2.21 ± 0.79 × 10(-3)mmHg(-1), p = 0.181) nor in PWV (8.69 ± 6.76 vs. 10.23 ± 7.88 ms(-1), p = 0.301) at 6 m. CONCLUSIONS: Treatment of symptomatic severe aortic stenosis by SAVR but not TAVI was associated with an increase in aortic stiffness at 6 months. Future work should focus on the prognostic implication of these findings to determine whether improved patient selection and outcomes can be achieved.
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Musa et al. (2016) conducted a cohort in Severe aortic stenosis (n=72). Surgical aortic valve replacement (SAVR) vs. Transcatheter aortic valve implantation (TAVI) was evaluated on Aortic pulse wave velocity (PWV) at 6 months. Treatment of symptomatic severe aortic stenosis by SAVR, but not TAVI, was associated with a significant increase in aortic pulse wave velocity from 6.38 to 11.01 m/s (p=0.001) at 6 months.
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