Key result
Regional multiphase vaccination halted a 38-case wild poliovirus outbreak within ~6 months of identification.
Why the study?
Outbreaks of wild poliovirus in polio-free regions experiencing active conflict, chronic insecurity, and large-scale displacement pose a substantial risk to global eradication because of disrupted health care and immunization services.
Observational (n=38)
Yes
A concerted response plan can successfully contain and interrupt polio outbreaks within 6 months even in settings of conflict and political instability.
May guide emergency responses in conflict zones; leaves open optimal strategies for sustained global eradication.
As the world advances toward the eradication of polio, outbreaks of wild poliovirus (WPV) in polio-free regions pose a substantial risk to the timeline for global eradication. Countries and regions experiencing active conflict, chronic insecurity, and large-scale displacement of persons are particularly vulnerable to outbreaks because of the disruption of health care and immunization services (1). A polio outbreak occurred in the Middle East, beginning in Syria in 2013 with subsequent spread to Iraq (2). The outbreak occurred 2 years after the onset of the Syrian civil war, resulted in 38 cases, and was the first time WPV was detected in Syria in approximately a decade (3,4). The national governments of eight countries designated the outbreak a public health emergency and collaborated with partners in the Global Polio Eradication Initiative (GPEI) to develop a multiphase outbreak response plan focused on improving the quality of acute flaccid paralysis (AFP) surveillance* and administering polio vaccines to >27 million children during multiple rounds of supplementary immunization activities (SIAs).† Successful implementation of the response plan led to containment and interruption of the outbreak within 6 months of its identification. The concerted approach adopted in response to this outbreak could serve as a model for responding to polio outbreaks in settings of conflict and political instability.
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Mbaeyi et al. (2017) conducted an observational in Wild poliovirus type 1 (WPV1) outbreak / acute flaccid paralysis (n=38). Multiphase polio outbreak response plan (supplementary immunization activities with trivalent and bivalent oral poliovirus vaccine and intensified acute flaccid paralysis surveillance) was evaluated on Containment and interruption of wild poliovirus type 1 transmission. A multiphase outbreak response plan vaccinating >27 million children across eight Middle Eastern countries interrupted a 38-case wild poliovirus outbreak within 6 months of identification.
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