Key result
In patients with Brugada syndrome, late potentials (P=0.023) and a family history of sudden cardiac death (P=0.0017) were significantly correlated with symptoms.
Why the study?
Do spatial and transmural repolarization parameters measured by 187-channel ECG correlate with ECG type and symptoms in patients with Brugada syndrome?
Observational (n=45)
Do spatial and transmural repolarization parameters measured by 187-channel ECG correlate with ECG type and symptoms in patients with Brugada syndrome?
p-value: p=0.023
In Brugada syndrome, conduction disturbances (late potentials) and family history of sudden cardiac death correlate with symptoms, suggesting conduction abnormalities contribute to malignant arrhythmias alongside repolarization abnormalities.
May refine symptom risk stratification in Brugada syndrome; leaves open prospective validation of late potentials and family history.
Background Vector‐projected 187‐channel electrocardiograms (ECGs) were recorded in 45 patients with a Brugada‐type ECG to evaluate spatial and transmural repolarization and dispersion of action potential duration in Brugada syndrome (BS). Methods Corrected recovery time (RT‐c, R wave peak to the first positive maximum derivative of the T wave with Bazett correction) and RT‐c dispersion were calculated. The corrected T peak‐end interval (T(p‐e)‐c, T wave peak to the end of the T wave with Bazett correction) and T(p‐e)‐c dispersion were calculated. Results RT‐c dispersion and T(p‐e)‐c interval were longer in patients with a type 1 ECG, but there was no significant difference in Tp‐e dispersion between patients with a type 1 and those with a type 2/3 ECG. No significant correlation was noted between RT‐c dispersion, T(p‐e)‐c dispersion, and symptoms. Late potentials ( P =0.023) and a family history of sudden cardiac death ( P =0.0017) were correlated with symptoms. Conclusions Spatial dispersion of repolarization may constitute the electrocardiographic pattern of the Brugada type ECG and conduction disturbance in addition to repolarization abnormality may contribute to the development of malignant ventricular tachyarrhythmias.
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Ohkubo et al. (2013) conducted an observational in Brugada syndrome (n=45). Brugada type 1 ECG, late potentials, and family history of sudden cardiac death vs. Brugada type 2/3 ECG or absence of risk factors was evaluated on Correlation with symptoms (p=0.023). In patients with Brugada syndrome, late potentials (P=0.023) and a family history of sudden cardiac death (P=0.0017) were significantly correlated with symptoms.
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