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Aged germfree Wistar rats developed benign tumors of the endocrine glands and/or their target organs. As the animals aged beyond 30 months, they had increasing numbers of endocrine tumors with some evidence of malignant transformation. Four spontaneousadenocarcinomas of the prostate, 3 with metastases and leukemoid reactions, were described.
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Morris Pollard (1973) studied this question.
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