Key result
Thrombolysis prevents hemodynamic collapse in intermediate-risk pulmonary embolism but increases the risk of major bleeding, particularly in patients over 75 years of age.
Why the study?
Does thrombolysis prevent hemodynamic collapse in patients with massive and submassive pulmonary embolism?
Population
Patients with high-risk (massive) and intermediate-risk (submassive) pulmonary embolism
Design
Review
Authors
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May warrant caution with thrombolysis in intermediate-risk PE patients >75 years; leaves open optimal dosing and catheter-based alternatives.
Does thrombolysis prevent hemodynamic collapse in patients with massive and submassive pulmonary embolism?
Thrombolysis is the treatment of choice for high-risk PE and should be considered in high-intermediate risk PE patients ≤75 years with low bleeding risk, while reduced dose or catheter-based therapies show promise.
Sanchez et al. (2014) conducted a review in massive and submassive pulmonary embolism. Thrombolysis was evaluated. Thrombolysis prevents hemodynamic collapse in intermediate-risk pulmonary embolism but increases the risk of major bleeding, particularly in patients over 75 years of age.
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