Key result
Autopsy conducted 16 months after sirolimus-eluting stent implantation revealed remarkable persistent peri-strut calcification with infiltration of macrophages and giant cells.
Case Report (n=1)
This autopsy case report demonstrates that remarkable persistent calcification can occur around the struts of a sirolimus-eluting stent 16 months after implantation, potentially driven by macrophage-mediated inflammation.
May signal chronic stent reactions; hypothesis-generating and should not change practice.
Drug-eluting stents (DES) are widely used for the treatment of coronary artery disease, and a sirolimus-eluting stent (SES; Cypher) was the first DES introduced into clinical practice. Although pathological reactions of coronary arteries to SES have been described in autopsy cases, there are few reports regarding calcification of the coronary arteries after SES implantation. The present report describes the findings of an autopsy conducted 16 months after SES implantation that showed remarkable persistent calcification. In addition, previously reported pertinent pathological findings are also described.
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Kawano et al. (2016) conducted a case report in Coronary artery disease (n=1). Sirolimus-eluting stent (SES) was evaluated on Pathological findings at autopsy (peri-strut calcification). Autopsy conducted 16 months after sirolimus-eluting stent implantation revealed remarkable persistent peri-strut calcification with infiltration of macrophages and giant cells.
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