Key result
Extensive mutagenesis demonstrated that 0 and +1 frame translation can be uncoupled, and the U-G base pair is not absolutely required for +1 frame translation.
This study provides a new paradigm for programmed recoding mechanisms that increase the coding capacity of a viral genome by showing how IRES conformations direct reading frame selection.
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Extends viral recoding models via IRES conformations; leaves open applicability beyond animal systems.
Ren et al. (2014) studied this question. Mutagenesis of IGR IRES vs. Wild-type IRES was evaluated on Translational reading frame selection. Extensive mutagenesis demonstrated that 0 and +1 frame translation can be uncoupled, and the U-G base pair is not absolutely required for +1 frame translation.
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