July 1, 1991Journal of Cardiovascular Pharmacology

The Effect of Pentoxifylline (Trental) and Two Analogues, BL 194 and HWA 448, on the Release of Plasminogen Activators and von Willebrand Factor in Rats

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Population

Rats (isolated perfused rat hindlegs and in vivo models)

Design

Preclinical

Authors

NTN. Tranquille JEJ. J. EmeisChristie's

Discussion

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Implication

Ex vivo effects on tPA and vWF release do not translate in vivo; leaves open relevance to intact animal models.

Structured PICO

Population

Rats (isolated perfused rat hindlegs and in vivo models)

Intervention

Pentoxifylline, BL 194 (penthydroxyfylline), and HWA 448 (torbafylline)

Outcome

Release of tissue-type plasminogen activator (tPA) and von Willebrand factor (vWF)surrogate

BL 194 demonstrates favorable effects on the thrombotic balance ex vivo by enhancing tPA and reducing vWF release, though these effects were not observed in vivo.

Cite This Study

Tranquille et al. (1991) studied this question.

synapsesocial.com/papers/6a7771bcdf493903fd1eef32 https://doi.org/10.1097/00005344-199107000-00006

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The Effect of Pentoxifylline (Trental) and Two Analogues, BL 194 and HWA 448, on the Release of Plasminogen Activators and von Willebrand Factor in Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Effect of Pentoxifylline (Trental) and Two Analogues, BL 194 and HWA 448, on the Release of Plasminogen Activators and von Willebrand Factor in Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider