Why the study?
Does pentoxifylline preloading reduce endothelial injury and permeability in patients undergoing cardiopulmonary bypass for elective CABG?
Population
40 patients undergoing cardiopulmonary bypass for elective coronary artery bypass grafting.
Comparison
Pentoxifylline 400 mg three times daily for 1… vs Placebo three times daily for 1 week before…
Design
RCT, randomized, parallel study, double blind, placebo controlled
Follow-up
24 hours after the end of CPB
Authors
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Supports preoperative pentoxifylline to limit CPB-induced endothelial injury in elective CABG; extends its anti-inflammatory effects to cardiac surgical settings.
Does pentoxifylline preloading reduce endothelial injury and permeability in patients undergoing cardiopulmonary bypass for elective CABG?
Preoperative administration of pentoxifylline attenuates endothelial injury and permeability associated with cardiopulmonary bypass during elective CABG.
Tsang et al. (1996) studied this question.
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