Why the study?
Does preoperative oral pentoxifylline improve respiratory index and reduce IL-6 production in adult patients undergoing cardiovascular surgery with cardiopulmonary bypass?
Population
30 adult patients undergoing cardiovascular surgery with cardiopulmonary bypass (CPB)
Comparison
Preoperative oral pentoxifylline 600 mg/day or… vs No pentoxifylline administration
Design
RCT, randomly separated into 2 experimental groups and 1 control group of 10…
Follow-up
postoperative day 1
Authors
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May support 900 mg/day preoperative pentoxifylline to limit post-CPB inflammation; extends dose-specific evidence in cardiac surgery RCTs.
Does preoperative oral pentoxifylline improve respiratory index and reduce IL-6 production in adult patients undergoing cardiovascular surgery with cardiopulmonary bypass?
Preoperative administration of 900 mg/day pentoxifylline for 5 days attenuates CPB-induced systemic inflammatory response and improves respiratory index in patients undergoing cardiovascular surgery.
Otani et al. (2008) studied this question.
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