January 1, 2005Perfusion

The intraoperative effect of pentoxifylline on the inflammatory process and leukocytes in cardiac surgery patients undergoing cardiopulmonary bypass

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Why the study?

Does intraoperative pentoxifylline reduce inflammatory markers in patients undergoing cardiopulmonary bypass for elective CABG?

Structured PICO

Does intraoperative pentoxifylline reduce inflammatory markers in patients undergoing cardiopulmonary bypass for elective CABG?

Population

60 patients undergoing cardiopulmonary bypass (CPB) for elective coronary artery bypass grafting (CABG)

Intervention

Pentoxifylline 200 mg added to 500 mL NaCl and perfused for 180 min after induction of anaesthesia, and 100 mg added to warm cardioplegic solution

Comparator

Saline solution as placebo

Outcome

Leukocyte counts, tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and C-reactive protein (CRP) levels up to 24 hours postoperativelysurrogate

Intraoperative pentoxifylline administration partially inhibits the systemic inflammatory response associated with cardiopulmonary bypass during CABG.

Discussion

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Implication

Reduces early inflammatory markers after elective CABG; confirms anti-inflammatory effect of intraoperative pentoxifylline and supports outcome trials.

Cite This Study

Çağlı et al. (2005) studied this question.

synapsesocial.com/papers/6a8c4297c12eaf65c8b23a49 https://doi.org/10.1191/0267659105pf779oa

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Implication

Reduces early inflammatory markers after elective CABG; confirms anti-inflammatory effect of intraoperative pentoxifylline and supports outcome trials.