Population
33 healthy lean male volunteers, aged 28.3+/-1.3 years (platelets used for in vitro experiments)
Comparison
In vitro incubation of platelets for 6 min with… vs Control conditions
Design
Preclinical
Follow-up
6 minutes (incubation)
Authors
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May activate platelet NO signaling osmotically in vitro; leaves open relevance to thrombotic risk in hyperglycemia.
High glucose rapidly activates the NO/cyclic nucleotide pathway in human platelets via an osmotic mechanism mediated by PKC-beta.
Massucco et al. (2005) studied this question.
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