Key result
In vitro incubation of human blood with high glucose levels enhanced platelet reactivity to agonist stimulation through elevated osmolality, superoxide anion production, and PKC signaling.
Why the study?
Do high glucose levels enhance platelet activation in fasting human blood?
Population
Fasting human blood
Comparison
Incubation with different concentrations of… vs Lower glucose concentrations or no stimuli
Design
Preclinical
Authors
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Hyperglycaemia may enhance platelet reactivity; leaves open whether glycaemic control reduces thrombotic risk in diabetes.
Do high glucose levels enhance platelet activation in fasting human blood?
High glucose levels enhance platelet reactivity to agonist stimulation through elevated osmolality, superoxide anion production, and PKC signaling, providing mechanistic insight into diabetes-associated platelet activation.
Sudić et al. (2006) studied this question. High glucose levels (D-glucose) vs. Baseline or other sugars was evaluated on Platelet activation (P-selectin expression and fibrinogen binding). In vitro incubation of human blood with high glucose levels enhanced platelet reactivity to agonist stimulation through elevated osmolality, superoxide anion production, and PKC signaling.