Key result
Insulin-induced hypoglycemia increases platelet sensitivity to aggregating agents and causes a release reaction in vivo, which is mediated by epinephrine via alpha-adrenergic receptors.
Why the study?
What are the mechanisms involved in hypoglycemia-induced platelet activation in healthy subjects?
Population
16 healthy male subjects, 7 fasting healthy subjects, and 4 healthy subjects
Follow-up
150 minutes
Authors
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Epinephrine mediates hypoglycemia-induced platelet activation; leaves open relevance to thrombotic risk in diabetes.
What are the mechanisms involved in hypoglycemia-induced platelet activation in healthy subjects?
Hypoglycemia-induced platelet activation is mediated by epinephrine acting through alpha-adrenergic receptors.
Trovati et al. (1986) studied Healthy subjects (n=16). Human regular insulin was evaluated on Platelet sensitivity to ADP, thrombin and platelet-activating factor; plasma concentrations of platelet markers. Insulin-induced hypoglycemia increases platelet sensitivity to aggregating agents and causes a release reaction in vivo, which is mediated by epinephrine via alpha-adrenergic receptors.
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