What question did this study set out to answer?

To evaluate whether acute insulin-induced hypoglycemia diminishes beta-adrenergic receptor sensitivity.

March 4, 1995Fundamental and Clinical Pharmacology

Reduced β‐adrenergic sensitivity in healthy volunteers induced by hypoglycemia

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Authors

TTT.S. TrovikUniversity Hospital of North Norway RJRagnhild JægerUiT The Arctic University of Norway RJRolf JordeUiT The Arctic University of Norway

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Implication

Controlled crossover study shows reduced beta-adrenergic sensitivity in healthy men after acute hypoglycemia, indicating a potential mechanism for hypoglycemia unawareness in type 1 diabetes.

Key Points

To evaluate whether acute insulin-induced hypoglycemia diminishes beta-adrenergic receptor sensitivity.
Enrolled 10 healthy male volunteers (aged 19–23 years) who stayed overnight on two separate occasions at the University Hospital of Tromsø.
Administered an intravenous injection of placebo (0.9% NaCl) during one visit and insulin (0.15 IU/kg) during the other to induce acute hypoglycemia.
Assessed beta-adrenergic responsiveness using the dose of isoprenaline required to raise heart rate by 25 bpm (I25) and the dose of metoprolol needed to block that rise by 50% (M-12.5).
Required doses of both I25 and M-12.5 significantly increased following hypoglycemia compared to placebo (p < 0.05).
The isoprenaline–heart rate dose-response curve shifted significantly to the right, demonstrating blunted cardiovascular sensitivity to beta-adrenergic stimulation.

Cite This Study

Trovik et al. (1995) studied this question.

synapsesocial.com/papers/6a9115c417bbbfe73e7459e4 https://doi.org/10.1111/j.1472-8206.1995.tb00279.x

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Implication

Controlled crossover study shows reduced beta-adrenergic sensitivity in healthy men after acute hypoglycemia, indicating a potential mechanism for hypoglycemia unawareness in type 1 diabetes.

Reduced β‐adrenergic sensitivity in healthy volunteers induced by hypoglycemia

Discussion

Member takes

Implication

Key Points

Cite This Study

Reduced β‐adrenergic sensitivity in healthy volunteers induced by hypoglycemia

Discussion

Member takes

Implication

Key Points

Cite This Study

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