Key result
Decreased isoproterenol sensitivity (requiring >3 micrograms to increase heart rate by 25 beats/min) was associated with fewer adrenergic symptoms and more hypoglycemic accidents.
Why the study?
Does isoproterenol sensitivity correlate with hypoglycemic symptoms and risk of hypoglycemic accidents in insulin-dependent diabetic patients?
Population
37 insulin-dependent diabetic patients
Design
Cross-sectional
Authors
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May flag high-risk patients for vigilance; leaves open whether testing improves outcomes in prospective studies.
Cross-Sectional (n=37)
Does isoproterenol sensitivity correlate with hypoglycemic symptoms and risk of hypoglycemic accidents in insulin-dependent diabetic patients?
The isoproterenol-sensitivity test can identify insulin-dependent diabetic patients at increased risk for hypoglycemic accidents due to decreased beta-adrenergic sensitivity.
Berlin et al. (1987) conducted a cross-sectional in Insulin-dependent diabetes (n=37). Isoproterenol sensitivity vs. High vs low sensitivity (I25 greater vs less than 3 micrograms) was evaluated on Adrenergic symptoms of hypoglycemia and hypoglycemic accidents. Decreased isoproterenol sensitivity (requiring >3 micrograms to increase heart rate by 25 beats/min) was associated with fewer adrenergic symptoms and more hypoglycemic accidents.
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