Lack of Hypoglycemic Symptoms and Decreasedβ-Adrenergic Sensitivity in Insulin-Dependent Diabetic Patients

10 men with insulin-dependent diabetes, divided into group A (n=5, adrenergic symptoms during hypoglycemia, no severe accidents) and group B (n=5, repeated severe hypoglycemic accidents, lack of adrenergic symptoms).

Insulin-induced hypoglycemia and isoproterenol sensitivity testing

Group A (patients with adrenergic symptoms) vs Group B (patients lacking adrenergic symptoms)

Plasma epinephrine, norepinephrine, and dopamine responses at rest, on standing, and during insulin-induced hypoglycemia; beta-adrenergic sensitivitysurrogate