Key result
Type I diabetes mellitus was associated with decreased beta-adrenergic sensitivity, requiring a higher isoproterenol dose to raise heart rate by 25 beats/min compared to normal subjects (4.07 vs 2.02 micrograms, P<0.01).
Why the study?
Does beta-adrenergic sensitivity differ in insulin-dependent diabetic patients compared to normal subjects?
Population
34 insulin-dependent diabetic patients and 10 age-matched normal subjects
Comparison
Isoproterenol sensitivity test vs Age-matched normal subjects
Design
Case-control
Authors
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Reduced beta-adrenergic sensitivity may alter responses to adrenergic agents in type 1 diabetes; leaves open effects on cardiovascular outcomes.
Observational (n=44)
Does beta-adrenergic sensitivity differ in insulin-dependent diabetic patients compared to normal subjects?
Absolute Event Rate: 4.07% vs 2.02%
p-value: p=<0.01
Patients with type I diabetes mellitus exhibit diminished beta-adrenergic sensitivity compared to normal subjects, which correlates with age and disease duration.
Berlin et al. (1986) conducted an observational in Insulin-dependent diabetes mellitus (n=44). Type I diabetes mellitus vs. Age-matched normal subjects was evaluated on Dose of isoproterenol required to increase the resting heart rate by 25 beat/min (I25) (p=<0.01). Type I diabetes mellitus was associated with decreased beta-adrenergic sensitivity, requiring a higher isoproterenol dose to raise heart rate by 25 beats/min compared to normal subjects (4.07 vs 2.02 micrograms, P<0.01).
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