Why the study?
Does isoprenaline stimulation induce a reduced cAMP response in mononuclear leucocytes from IDDM patients with hypoglycaemia unawareness compared to controls and IDDM-aware patients?
Does isoprenaline stimulation induce a reduced cAMP response in mononuclear leucocytes from IDDM patients with hypoglycaemia unawareness compared to controls and IDDM-aware patients?
IDDM patients with hypoglycaemia unawareness exhibit reduced beta-adrenergic sensitivity at the cellular level, as evidenced by decreased cAMP production in mononuclear leucocytes following isoprenaline stimulation.
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Reduced cAMP response in IDDM unawareness supports beta-adrenergic desensitization; case-control data leave causality and therapeutic relevance open.
Trovik et al. (1995) studied this question.
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