Key result
Atrial myocytes lack transverse tubules, causing calcium signals to originate peripherally and propagate centripetally, a pattern that ventricular myocytes adopt during heart failure.
Population
Mammalian atrial myocytes, neonatal ventricular myocytes, Purkinje cells, and failing ventricular myocytes
Design
Review
Authors
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May inform atrial arrhythmia mechanisms; leaves open whether T-tubule restoration alters ventricular remodeling in heart failure.
This review highlights the unique peripheral-to-central calcium signalling in atrial myocytes due to their lack of T-tubules, providing mechanistic insights applicable to heart failure where ventricular myocytes lose T-tubules.
Bootman et al. (2006) reported a review. Atrial myocytes lack transverse tubules, causing calcium signals to originate peripherally and propagate centripetally, a pattern that ventricular myocytes adopt during heart failure.
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