January 1, 2004Hypertension ResearchOpen Access

White-Coat Hypertension Contributes to the Presence of Carotid Arteriosclerosis

View Full Paper

Ask AI

Bookmark

Why the study?

Does white-coat hypertension increase carotid intimal-medial thickness and cross-sectional area compared to normotension in Japanese adults?

Structured PICO

Does white-coat hypertension increase carotid intimal-medial thickness and cross-sectional area compared to normotension in Japanese adults?

Population

90 Japanese individuals (n=30 with white-coat hypertension, n=30 with untreated sustained hypertension without carotid plaques, n=30 normotensive subjects). Mean age 54-58 years, 33% male. Key inclusion: no clinical signs of secondary hypertension, no coexisting cardiovascular disease, normal lab findings.

Intervention

White-coat hypertension (observational exposure)

Comparator

Untreated sustained hypertension (matched for clinical BP) and normotension (matched for ambulatory BP)

Outcome

Carotid intimal-medial thickness (IMT) and cross-sectional area (CSA) of the common carotid artery measured by B-mode ultrasonographysurrogate

White-coat hypertension is associated with increased carotid arteriosclerosis comparable to sustained mild hypertension, highlighting the need to evaluate these patients for target organ damage.

Limitations

Patients with sustained hypertension were only mildly hypertensive; more severe hypertension might have shown greater IMT/CSA differences.
Excluded hypertensive patients with plaque formation in the carotid arteries.
Did not measure postchallenge plasma glucose or glycemic spikes, which could be associated with carotid IMT.
Peripheral sympathetic hyperactivity was not measured.
Did not measure other vascular organ damages, such as carotid and aortic distensibility or aortic calcification (e.g., baPWV).

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May warrant carotid assessment in white-coat hypertension; leaves open whether risk equals sustained hypertension long-term.

Cite This Study

Nakashima et al. (2004) studied this question.

synapsesocial.com/papers/6a777b4dd8eb58afc2bde64d https://doi.org/10.1291/hypres.27.739

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

White-Coat Hypertension Contributes to the Presence of Carotid Arteriosclerosis

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Topics

White-Coat Hypertension Contributes to the Presence of Carotid Arteriosclerosis

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider