Key result
Percutaneous balloon mitral valvulotomy significantly increased mean mitral valve area from 0.85 cm2 to 1.60 cm2 (p<0.0001) in pregnant patients with severe mitral stenosis.
Why the study?
Does percutaneous balloon mitral valvulotomy improve mitral valve area and gradients in pregnant females with severe mitral stenosis?
Observational (n=30)
No
Does percutaneous balloon mitral valvulotomy improve mitral valve area and gradients in pregnant females with severe mitral stenosis?
Percutaneous balloon mitral valvulotomy is safe and effective in pregnant patients with severe mitral stenosis, significantly improving mitral valve area and gradients.
Answers are grounded in this paper and cite their sources.
Supports percutaneous balloon mitral valvulotomy in pregnant severe mitral stenosis; leaves open need for confirmatory trials.
INTRODUCTION: In pregnant women mitral stenosis is the commonest cardiac valvular lesion. When it is present in majorly severe condition it leads to maternal and fetal morbidity and mortality. In mitral stenosis pregnancy can lead to development of heart failure. AIM: To evaluate the safety and efficacy of balloon mitral valvulotomy (BMV) in pregnant females with severe mitral stenosis. MATERIALS AND METHODS: A total of 30 pregnant patients who underwent BMV were included in the study from July 2011 to November 2013. Clinical follow-up during pregnancy was done every 3 months until delivery and after delivery. The mean follow up time after BMV was 6.72±0.56 months. RESULTS: From the 30 pregnant females 14 (46.67%) and 16 (53.3%) patients underwent BMV during the third and second trimester of pregnancy respectively. The mean mitral valve area was 0.85+0.16 cm(2) before BMV that increased to 1.60+0.27 cm(2) (p<0.0001) immediately after BMV. Peak and mean diastolic gradients had decreased significantly within 48 hours after the procedure (p<0.001) but remained very much unchanged at 6.72 month period of follow-up. Two patients had an increase in mitral regurgitation by 2 grades. CONCLUSION: During pregnancy BMV technique is safe and effective in patients with severe mitral stenosis. This results in marked symptomatic relief along with long term maternal and fetal outcomes.
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Joshi et al. (2015) conducted an observational in Severe mitral stenosis in pregnancy (n=30). Percutaneous balloon mitral valvulotomy vs. Baseline (pre-procedure) was evaluated on Mean mitral valve area (p=<0.0001). Percutaneous balloon mitral valvulotomy significantly increased mean mitral valve area from 0.85 cm2 to 1.60 cm2 (p<0.0001) in pregnant patients with severe mitral stenosis.
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