Key result
Aldosterone treatment increased cell size by 61% in rat neonatal ventricular myocytes, demonstrating a direct hypertrophic effect that is dependent on NHE-1 activity.
Population
rat neonatal ventricular myocytes
Design
Preclinical
Follow-up
24 hours
Authors
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Direct hypertrophic effect in neonatal myocytes warrants clinical caution; leaves open NHE-1 as a therapeutic target in human cardiac disease.
Aldosterone exerts a direct hypertrophic effect on cultured ventricular myocytes that is dependent on NHE-1 activity.
Karmazyn et al. (2003) studied this question. Aldosterone was evaluated on Hypertrophic responses (cell size). Aldosterone treatment increased cell size by 61% in rat neonatal ventricular myocytes, demonstrating a direct hypertrophic effect that is dependent on NHE-1 activity.
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