Key result
Intermittent vagal blocking in obese subjects with type 2 diabetes resulted in 25% excess weight loss and a 1.0% reduction in HbA1c at 12 months (P<0.0001 and P=0.02, respectively).
Why the study?
Does intermittent vagal blocking improve weight loss, glycemic control, and blood pressure in obese subjects with type 2 diabetes mellitus?
Population
28 obese subjects with type 2 diabetes mellitus, mean age 51 ± 2 years, BMI 37 ± 1 kg/m2, 17 females/9 males.
Design
Cohort, open-label
Follow-up
12 months
Authors
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Should not yet change practice in obese T2DM; leaves open efficacy and safety in randomized trials.
Does intermittent vagal blocking improve weight loss, glycemic control, and blood pressure in obese subjects with type 2 diabetes mellitus?
p-value: p=<0.0001
Intermittent vagal blocking in obese patients with type 2 diabetes is associated with significant weight loss, improved HbA1c, and reduced blood pressure at 12 months.
Shikora et al. (2013) studied Obesity with Type 2 Diabetes Mellitus (n=28). Intermittent vagal blocking (VBLOC) was evaluated on excess weight loss percentage (% EWL) at 12 months (p=<0.0001). Intermittent vagal blocking in obese subjects with type 2 diabetes resulted in 25% excess weight loss and a 1.0% reduction in HbA1c at 12 months (P<0.0001 and P=0.02, respectively).
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