Key result
Noncompaction cardiomyopathy was associated with a significantly increased aortic stiffness index compared to healthy controls (8.3 vs. 3.5, p < 0.001).
Why the study?
Is aortic stiffness increased in patients with noncompaction cardiomyopathy compared to healthy controls?
Case-Control (n=40)
No
Is aortic stiffness increased in patients with noncompaction cardiomyopathy compared to healthy controls?
Absolute Event Rate: 8.3% vs 3.5%
p-value: p=<0.001
Patients with noncompaction cardiomyopathy exhibit significantly increased aortic stiffness compared to healthy controls, which may be related to neurohormonal changes in heart failure.
May signal vascular involvement in noncompaction cardiomyopathy; hypothesis-generating and should not change practice.
BACKGROUND: Noncompaction cardiomyopathy (NCCM) is a recently recognized disorder frequently associated with systolic and diastolic heart failures. This study was designed to examine aortic stiffness in NCCM patients and to compare these results to age- and gender-matched controls. METHODS: A total of 20 patients with typical echocardiographic features of NCCM (age 38 +/- 16 years, eight males) were investigated. Their results were compared to 20 age- and gender-matched controls. All subjects underwent a complete two-dimensional transthoracic echocardiographic examination. Systolic (SD) and diastolic (DD) ascending aortic diameters were recorded in M-mode at a level of 3 cm above the aortic valve from a parasternal long-axis view. Aortic stiffness index (beta) was calculated as a characteristic of aortic elasticity, as ln(SBP/DBP)/[(SD - DD)/DD], where SBP and DBP are the systolic and diastolic blood pressures, respectively, and ln is the natural logarithm. RESULTS: The number of noncompacted segments in the NCCM patients was 4.6 +/- 2.0. NCCM patients had significantly increased left ventricular dimensions and reduced left ventricular ejection fraction. Compared to controls, aortic stiffness index (beta) was significantly increased in NCCM patients (8.3 +/- 5.2 vs. 3.5 +/- 1.1, p < 0.001). CONCLUSION: Increased aortic stiffness can be observed in patients with NCCM with moderate to severe heart failure. These alterations may be due to neurohormonal changes in heart failure.
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Nemes et al. (2007) conducted a case-control in Noncompaction cardiomyopathy (n=40). Noncompaction cardiomyopathy vs. Age- and gender-matched controls was evaluated on Aortic stiffness index (β) (p=<0.001). Noncompaction cardiomyopathy was associated with a significantly increased aortic stiffness index compared to healthy controls (8.3 vs. 3.5, p < 0.001).
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