Aortic input impedance in heart failure.
Key result
Heart failure patients had significantly increased input resistance and characteristic impedance compared to matched controls, indicating increased aortic stiffness and wave reflections.
Why the study?
Is aortic input impedance altered in patients with heart failure compared to matched controls?
Population
20 patients: 10 with clinical and hemodynamic evidence of heart failure, and 10 pressure- and age-matched…
Design
Case-control
Authors
Discussion
Loading...
Member takes
Implication
May worsen pulsatile load in heart failure; leaves open whether impedance modulation improves outcomes.
Study Design
Type
Case-Control (n=20)
Structured PICO
Is aortic input impedance altered in patients with heart failure compared to matched controls?
P
Population
20 patients: 10 with clinical and hemodynamic evidence of heart failure, and 10 pressure- and age-matched control subjects without clinical evidence of heart failure.
C
Comparator
10 pressure- and age-matched control subjects without clinical evidence of heart failure
O
Outcome
Aortic input impedance (input resistance and characteristic impedance)surrogate
Heart failure is associated with increased aortic stiffness and wave reflections, which may negatively impact the pulsatile function of the failing left ventricle.
Cite This Study
Pepine et al. (1978) conducted a case-control in Heart failure (n=20). Heart failure (exposure) vs. Control subjects without heart failure was evaluated on Input resistance, characteristic impedance, and oscillations of impedance moduli. Heart failure patients had significantly increased input resistance and characteristic impedance compared to matched controls, indicating increased aortic stiffness and wave reflections.