Key result
Heart failure patients exhibited increased peripheral resistance and wave reflection compared to normal subjects, which decreased during nitroprusside infusion.
Why the study?
How does aortic input impedance differ between heart failure patients and normal subjects, and how does it change during vasodilator therapy with nitroprusside?
Population
12 patients with congestive heart failure and 11 normal subjects (total n=23)
Comparison
Nitroprusside infusion vs Normal subjects and pre-infusion control…
Design
Other
Authors
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Nitroprusside may acutely reduce impedance in HF; Level 5 data leaves open outcome benefits.
Observational (n=23)
How does aortic input impedance differ between heart failure patients and normal subjects, and how does it change during vasodilator therapy with nitroprusside?
In heart failure, increased aortic impedance is driven by greater peripheral resistance and wave reflection, which can be acutely reduced by vasodilator therapy with nitroprusside.
Merillon et al. (1984) conducted an observational in Congestive heart failure (n=23). Nitroprusside infusion vs. Baseline (control conditions) and normal subjects was evaluated on Aortic impedance (impedance modulus at 0 Hz and low frequencies). Heart failure patients exhibited increased peripheral resistance and wave reflection compared to normal subjects, which decreased during nitroprusside infusion.
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