Key result
Heart failure was associated with similar resting characteristic impedance compared to normal subjects (93 vs 85 dyne-sec-cm-5), with exercise imposing no additional increase in hydraulic load.
Why the study?
How does vascular hydraulic load differ between patients with heart failure and normal subjects at rest and during exercise?
Observational (n=19)
How does vascular hydraulic load differ between patients with heart failure and normal subjects at rest and during exercise?
Absolute Event Rate: 93% vs 85%
In patients with heart failure, the pulsatile component of vascular hydraulic load is similar to normal subjects and does not increase during exercise, suggesting no additional hydraulic load is imposed on the ejecting left ventricle.
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Similar pulsatile load in HF at rest/exercise may not add hydraulic burden; leaves open its impact on outcomes and targeted interventions.
Laskey et al. (1985) conducted an observational in Heart failure secondary to idiopathic congestive cardiomyopathy (n=19). Exercise vs. Normal subjects was evaluated on Characteristic impedance (Zc). Heart failure was associated with similar resting characteristic impedance compared to normal subjects (93 vs 85 dyne-sec-cm-5), with exercise imposing no additional increase in hydraulic load.
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