June 1, 1989British Journal of PharmacologyOpen Access

Involvement of the protein kinase C system in calcium‐force relationships in ferret aorta

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Population

Ferret aortic smooth muscle

Comparison

Protein kinase C activation with… vs Control conditions

Design

Preclinical

Authors

ARAndre L. RuzyckyUniversity of Pittsburgh KMKathleen G. MorganVascular Medicine

Discussion

Member takes

Implication

Animal data link PKC to enhanced vascular Ca2+ sensitivity; leaves open translation to human myogenic tone or therapy.

Structured PICO

Population

Ferret aortic smooth muscle

Intervention

Protein kinase C activation with 12-deoxyphorbol-13-isobutyrate 20 acetate (DPBA) or inhibition with H-7

Comparator

Control conditions (K+ depolarization or resting state)

Outcome

Intracellular Ca2+-force relationships (measured by aequorin luminescence and isometric force)surrogate

Protein kinase C appears to be an important regulator of vascular smooth muscle contractility by increasing calcium sensitivity and maintaining intrinsic myogenic tone.

Cite This Study

Ruzycky et al. (1989) studied this question.

synapsesocial.com/papers/6a7789247ecc675f86ae7af7 https://doi.org/10.1111/j.1476-5381.1989.tb11966.x

View Full Paper

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Bookmark

Involvement of the protein kinase C system in calcium‐force relationships in ferret aorta

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Involvement of the protein kinase C system in calcium‐force relationships in ferret aorta

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider