Population
32P-labeled rabbit aorta tissue
Comparison
Stimulation by phorbol 12,13-dibutyrate or… vs Controls using purified components
Design
Preclinical
Authors
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These rabbit aorta findings warrant clinical caution; leaves open distinct PKC versus MLCK roles in human vascular contraction.
In rabbit aorta, the contractile effects of PDB may be partially mediated by Ca2+-dependent activation of myosin light chain kinase, while phenylephrine does not result in protein kinase C-mediated myosin light chain phosphorylation.
Singer et al. (1989) studied this question.
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