Key result
In patients with untreated first-episode major depressive disorder, TyG-BMI exhibited a U-shaped relationship with suicide attempts, with risk increasing above an inflection point of 210 (OR 1.012) and below it (OR 0.985).
Why the study?
The triglyceride glucose-body mass index (TyG-BMI) is an alternative metric for insulin resistance, but its relationship with suicide attempts was unclear.
Does the TyG-BMI index correlate with suicide attempts in patients with untreated first-episode major depressive disorder?
Cross-Sectional (n=1,718)
No
Does the TyG-BMI index correlate with suicide attempts in patients with untreated first-episode major depressive disorder?
Odds Ratio: 1.012 (95% CI 1.003–1.047)
p-value: p=0.005
In patients with untreated first-episode major depressive disorder, there is a U-shaped relationship between the TyG-BMI index and suicide attempts, suggesting both low and high levels may be associated with increased risk.
Observed U-shaped TyG-BMI–SA association in UFE MDD is hypothesis-generating; leaves open any clinical role pending prospective validation.
OBJECTIVE: An alternative metric for evaluating insulin resistance (IR) is the triglyceride glucose-body mass index (TyG-BMI). However, it is yet unclear how TyG-BMI and suicide attempts (SA) are related. The objective of this research was to explore the correlation between the TyG-BMI index and SA in individuals with untreated first-episode (UFE) major depressive disorder (MDD) in Shanxi Province. METHODS: This cross-sectional study was conducted from September 2016 to December 2018 in the psychiatric outpatient clinic of Taiyuan General Hospital and included 1718 patients with UFE MDD, with a mean age of 34.9 ± 12.4 years. The relationship between TyG-BMI and SA was assessed using logistic regression modeling. We investigated threshold effects using a two-piecewise linear regression model. RESULTS: Taking into consideration the potential influence of confounding variables, a comprehensive multivariate logistic regression analysis was conducted, which demonstrated the absence of a statistically significant association between the TyG-BMI index and the occurrence of SA, as evidenced by P-values that were all greater than 0.05. On the other hand, the visual analysis of the smoothed plots revealed a U-shaped relationship between the TyG-BMI index and the incidence of SA, with a notable inflection occurring at a TyG-BMI value of around 210. It was observed that the effect sizes flanking the inflection point, accompanied by their 95% confidence intervals, were 0.985 (95% CI: 0.972 to 0.999, P = 0.031) and 1.012 (95% CI: 1.003 to 1.047, P = 0.005), respectively. CONCLUSIONS: In UFE MDD patients, a U-shaped link was observed between TyG-BMI and SA, with the minimal SA incidence noted at a TyG-BMI level of 210, signifying that an augmented risk for SA might be connected to both diminished and augmented TyG-BMI levels.
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Jia et al. (2024) conducted a cross-sectional in Untreated first-episode major depressive disorder (n=1,718). Triglyceride glucose-body mass index (TyG-BMI) was evaluated on Suicide attempts (TyG-BMI ≥ 210) (OR 1.012, 95% CI 1.003-1.047, p=0.005). In patients with untreated first-episode major depressive disorder, TyG-BMI exhibited a U-shaped relationship with suicide attempts, with risk increasing above an inflection point of 210 (OR 1.012) and below it (OR 0.985).
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