Key result
A higher triglyceride glucose index was significantly associated with an increased risk of suicide attempts in patients with first-episode drug-naïve major depressive disorder (OR 1.35), exhibiting a threshold effect above 9.29.
Why the study?
The triglyceride glucose index is an alternative indicator of insulin resistance, but its association with suicide attempts in major depressive disorder is unclear.
Is the triglyceride glucose index associated with the risk of suicide attempts in patients with first-episode drug-naïve major depressive disorder?
Cross-Sectional (n=1,718)
No
Is the triglyceride glucose index associated with the risk of suicide attempts in patients with first-episode drug-naïve major depressive disorder?
Odds Ratio: 1.35 (95% CI 1.04–1.75)
p-value: p=0.03
A higher triglyceride glucose index is non-linearly associated with an increased risk of suicide attempts in Chinese patients with first-episode drug-naïve major depressive disorder, particularly when the index exceeds 9.29.
Higher TyG (>9.29) was associated with increased SA risk in FEDN MDD; leaves open causal role and screening utility pending prospective data.
Objective Triglyceride glucose (TyG) index has been suggested as an alternative indicator of insulin resistance (IR); however, the association between TyG index and suicide attempts (SA) in major depressive disorder (MDD) is unclear. The aim of this study was to investigate the relationship between TyG index and SA in Chinese patients with first-episode drug-naïve (FEDN) MDD. Methods This cross-sectional study enrolled 1,718 patients with FEDN MDD aged 34.9 ± 12.4 years from the First Hospital of Shanxi Medical University (Taiyuan, Shanxi Province, China) from September 2016 to December 2018. Multivariable binary logistic regression analysis was used to estimate the association between TyG index and the risk of SA. A two-piecewise linear regression model was used to investigate the threshold effects if non-linearity associations existed. Interaction and stratified analyses were performed based on sex, education, marital status, comorbid anxiety, and psychotic symptoms. Results Multivariable logistic regression analysis revealed that TyG index was positively associated with the risk of SA after adjusting for confounders (OR = 1.35, 95% CI: 1.04–1.75, p = 0.03). Smoothing plots also showed a nonlinear relationship between TyG index and SA, with the inflection point of TyG index being 9.29. On the right of the inflection point, a positive association between TyG index and SA was detected (OR = 3.47, 95% CI: 1.81 to 6.66, p < 0.001), while no significant association was observed on the left side of the inflection point (OR = 1.14, 95% CI: 0.79 to 1.66, p = 0.476). Conclusion The relationship between TyG index and SA risk was non-linear and exhibited a threshold effect in Chinese patients with FEDN MDD. When TyG index was greater than 9.29, they showed a significant positive correlation.
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Liu et al. (2023) conducted a cross-sectional in First-episode drug-naïve major depressive disorder (n=1,718). Triglyceride glucose (TyG) index vs. Lower TyG index was evaluated on Risk of suicide attempts (OR 1.35, 95% CI 1.04-1.75, p=0.03). A higher triglyceride glucose index was significantly associated with an increased risk of suicide attempts in patients with first-episode drug-naïve major depressive disorder (OR 1.35), exhibiting a threshold effect above 9.29.
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